LAVECCHIA, ANTONIO
LAVECCHIA, ANTONIO
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties
2024-01-01 Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Montanari, Roberta; Capelli, Davide; Wackerlig, Judith; Simic, Stefan; Falbo, Emanuele; Pecora, Lucia; Leuci, Rosalba; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Sudeep, C. A.; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition
2023-01-01 Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Pratap Singh, Ravi; Tambe, Suhas; Ca, Sudeep; Kumar Pattnaik, Ashok; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
Discovery of a dual PPARα/γ partial agonist displaying antisteatotic and antidiabetic properties: in silico studies and X-ray structure determination
2024-01-01 Cerchia, Carmen; Laghezza, Antonio; Brunetti, Leonardo; Falbo, Emanuele; Tortorella, Paolo; Piemontese, Luca; Montanari, Roberta; Paoli, Paolo; Jayaprakash, Venkatesan; Loiodice, Fulvio; Lavecchia, Antonio
Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies.
2020-01-01 Ammazzalorso, Alessandra; Bruno, Isabella; Florio, Rosalba; De Lellis, Laura; Laghezza, Antonio; Cerchia, Carmen; De Filippis, Barbara; Fantacuzzi, Marialuigia; Giampietro, Letizia; Maccallini, Cristina; Tortorella, Paolo; Veschi, Serena; Loiodice, Fulvio; Lavecchia, Antonio; Cama, Alessandro; Amoroso, Rosa
Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine-2,5-dione Hybrids as Potential Antitumor Agents
2020-01-01 Tilekar, Kalpana; Upadhyay, Neha; Meyer‐almes, Franz‐josef; Loiodice, Fulvio; Anisimova, Natalia Y.; Spirina, Tatiana S.; Sokolova, Darina V.; Smirnova, Galina B.; Choe, Jun‐yong; Pokrovsky, Vadim S.; Lavecchia, Antonio; Ramaa, C. S.
Thiazolidinedione "magic Bullets" Simultaneously Targeting PPARγand HDACs: Design, Synthesis, and Investigations of their in Vitro and in Vivo Antitumor Effects
2021-01-01 Tilekar, K.; Hess, J. D.; Upadhyay, N.; Bianco, A. L.; Schweipert, M.; Laghezza, A.; Loiodice, F.; Meyer-Almes, F. -J.; Aguilera, R. J.; Lavecchia, A.; Ramaa, C. S.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties | 1-gen-2024 | Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Montanari, Roberta; Capelli, Davide; Wackerlig, Judith; Simic, Stefan; Falbo, Emanuele; Pecora, Lucia; Leuci, Rosalba; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Sudeep, C. A.; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition | 1-gen-2023 | Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Pratap Singh, Ravi; Tambe, Suhas; Ca, Sudeep; Kumar Pattnaik, Ashok; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| Discovery of a dual PPARα/γ partial agonist displaying antisteatotic and antidiabetic properties: in silico studies and X-ray structure determination | 1-gen-2024 | Cerchia, Carmen; Laghezza, Antonio; Brunetti, Leonardo; Falbo, Emanuele; Tortorella, Paolo; Piemontese, Luca; Montanari, Roberta; Paoli, Paolo; Jayaprakash, Venkatesan; Loiodice, Fulvio; Lavecchia, Antonio | |
| Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies. | 1-gen-2020 | Ammazzalorso, Alessandra; Bruno, Isabella; Florio, Rosalba; De Lellis, Laura; Laghezza, Antonio; Cerchia, Carmen; De Filippis, Barbara; Fantacuzzi, Marialuigia; Giampietro, Letizia; Maccallini, Cristina; Tortorella, Paolo; Veschi, Serena; Loiodice, Fulvio; Lavecchia, Antonio; Cama, Alessandro; Amoroso, Rosa | |
| Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine-2,5-dione Hybrids as Potential Antitumor Agents | 1-gen-2020 | Tilekar, Kalpana; Upadhyay, Neha; Meyer‐almes, Franz‐josef; Loiodice, Fulvio; Anisimova, Natalia Y.; Spirina, Tatiana S.; Sokolova, Darina V.; Smirnova, Galina B.; Choe, Jun‐yong; Pokrovsky, Vadim S.; Lavecchia, Antonio; Ramaa, C. S. | |
| Thiazolidinedione "magic Bullets" Simultaneously Targeting PPARγand HDACs: Design, Synthesis, and Investigations of their in Vitro and in Vivo Antitumor Effects | 1-gen-2021 | Tilekar, K.; Hess, J. D.; Upadhyay, N.; Bianco, A. L.; Schweipert, M.; Laghezza, A.; Loiodice, F.; Meyer-Almes, F. -J.; Aguilera, R. J.; Lavecchia, A.; Ramaa, C. S. |