PATI, MARIA LAURA
PATI, MARIA LAURA
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents
2015-01-01 Pati, MARIA LAURA; Abate, CARMEN rosa; Contino, Marialessandra; Ferorelli, Savina; Luisi, Renzo; Laura, Carroccia; Niso, Mauro; Berardi, Francesco
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors
2016-01-01 Abate, CARMEN rosa; Riganti, Chiara; Pati, MARIA LAURA; Ghigo, Dario; Berardi, Francesco; Mavlyutov, Timur; Guo, Lian Wang; Ruoho, Arnold
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump
2015-01-01 Abate, C; Pati, Maria Laura; Contino, M; Colabufo, N A; Perrone, R; Niso, M; Berardi, F
Intelligent microarray data analysis through non-negative matrix factorization to study human multiple myeloma cell lines
2019-01-01 Casalino, G.; Coluccia, M.; Pati, M. L.; Pannunzio, A.; Vacca, A.; Scilimati, A.; Perrone, M. G.
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors
2018-01-01 Pati, Maria Laura; Niso, Mauro; Spitzer, Dirk; Berardi, Francesco; Contino, Marialessandra; Riganti, Chiara; Hawkins, William G.; Abate, Carmen
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells
2015-01-01 Niso, Mauro; Riganti, Chiara; Pati, MARIA LAURA; Ghigo, Dario; Berardi, Francesco; Abate, CARMEN rosa
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment
2015-01-01 Pati, MARIA LAURA; Niso, Mauro; Ferorelli, Savina; Abate, CARMEN rosa; Berardi, Francesco
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma
2021-01-01 Scilimati, A; Miciaccia, M; Pati, Ml; Ferorelli, S; Giampietro, R; Contino, M; Vacca, A; Leone, P; Racanelli, V; Perrone, Mg
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging
2018-01-01 Pati, Maria Laura; Fanizza, Elisabetta; Hager, Sonja; Groza, Diana; Heffeter, Petra; Laurenza, Amelita Grazia; Laquintana, Valentino; Curri, Maria Lucia; Depalo, Nicoletta; Abate, Carmen; Denora, Nunzio
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer
2016-01-01 Niso, Mauro; Pati, MARIA LAURA; Berardi, Francesco; Abate, CARMEN rosa
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer
2017-01-01 Pati, MARIA LAURA; Hornick, John R.; Niso, Mauro; Berardi, Francesco; Spitzer, Dirk; Abate, CARMEN rosa; Hawkins, William
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1
2017-01-01 Pati, MARIA LAURA; Groza, Diana; Riganti, Chiara; Kopecka, Joanna; Niso, Mauro; Berardi, Francesco; Hager, Sonja; Heffeter, Petra; Hirai, Miwa; Tsugawa, Hitoshi; Kabe, Yasuaki; Suematsu, Makoto; Abate, CARMEN rosa
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics
2016-01-01 Pati, MARIA LAURA; Abate, CARMEN rosa; Niso, Mauro; Berardi, Francesco; Colabufo, Nicola Antonio
Synthesis, radiolabelling, and evaluation of [11C]PB212 as a radioligand for imaging sigma-1 receptors using PET.
2018-01-01 Francesco, Spinelli; Ahmed, Haider; Toscano, Annamaria; Pati, MARIA LAURA; Claudia, Keller; Berardi, Francesco; Colabufo, Nicola Antonio; Abate, Carmen; Simon, M Ametamey:
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection
2019-01-01 Scilimati, A.; Ferorelli, S.; Iaselli, M. C.; Miciaccia, M.; Pati, M. L.; Fortuna, C. G.; Aleem, A. M.; Marnett, L. J.; Perrone, M. G.
The concomitant effect of anti-MM drugs in combination with COX inhibitors
2017-01-01 Pati, MARIA LAURA; Scilimati, Antonio; Perrone, MARIA GRAZIA
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities?
2015-01-01 Abate, CARMEN rosa; Niso, Mauro; Pati, MARIA LAURA; Colabufo, Nicola Antonio; Berardi, Francesco