Sfoglia per Autore
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases
2011-01-01 Pisani, Leonardo; Catto, Marco; Leonetti, Francesco; Nicolotti, Orazio; Stefanachi, Angela; Campagna, Francesco; Carotti, Angelo
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors
2011-01-01 Stefanachi, Angela; Favia, A. D.; Nicolotti, Orazio; Leonetti, F; Pisani, Leonardo; Catto, Marco; Zimmer, C; Hartmann, R. W.; Carotti, Angelo
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease
2011-01-01 Tasso, B; Catto, Marco; Nicolotti, Orazio; Novelli, F; Tonelli, M; Giangreco, I; Pisani, Leonardo; Sparatore, A; Boido, V; Carotti, Angelo; Sparatore, F.
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors
2011-01-01 Barletta, M.; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Soto Otero, R.; Carotti, Angelo
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase
2011-01-01 Stefanachi, Angela; Favia, Ad; Nicolotti, Orazio; Leonetti, Francesco; Pisani, Leonardo; Catto, Marco; Zimmer, C; Hartmann, Rw; Cellamare, Saverio; Carotti, Angelo
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity
2011-01-01 CONEJO GARCÍA, A; Pisani, Leonardo; DEL CARMEN NÚÑEZ, M; Catto, Marco; Nicolotti, Orazio; Leonetti, Francesco; Campos, J; Gallo, M; Espinosa, A; Carotti, Angelo
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams
2012-01-01 Leonetti, Francesco; Muncipinto, G; Stefanachi, Angela; Nicolotti, Orazio; Cellamare, Saverio; Catto, Marco; Pisani, Leonardo; Pellegrino, G; Carotti, Angelo
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia
2012-01-01 Stefanachi, Angela; Leonetti, Francesco; Nicolotti, Orazio; Catto, Marco; Pisani, Leonardo; Cellamare, Saverio; Altomare, Cosimo Damiano; Carotti, Angelo
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
2012-01-01 Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders
2013-01-01 Pisani, L.; Catto, M.; Stefanachi, A.; Leonetti, F.; Campagna, F.; Nicolotti, O.; Soto-Otero, R.; Carotti, A.
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS
2013-01-01 Pisani, Leonardo; Catto, Marco; Stefanachi, Angela; Leonetti, F; Campagna, Francesco; Nicolotti, O; SOTO OTERO, R; Carotti, A.
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors
2013-01-01 Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, G; Di Braccio, M; Soto Otero, R; Mendez Alvarez, E; Stefanachi, Angela; Gadaleta, G; Carotti, Angelo
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase
2013-01-01 Catto, Marco; Pisani, Leonardo; Leonetti, Francesco; Nicolotti, Orazio; Pesce, Paolo; Stefanachi, Angela; Cellamare, Saverio; Carotti, Angelo
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors
2013-01-01 Pisani, Leonardo; Barletta, Maria; Soto Otero, Ramon; Nicolotti, Orazio; Mendez Alvarez, Estefania; Catto, Marco; Introcaso, Antonellina; Stefanachi, Angela; Cellamare, Saverio; Altomare, Cosimo Damiano; Carotti, Angelo
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK
2014-01-01 Cellamare, Saverio; Carotti, Angelo; Stefanachi, Angela; Leonetti, Francesco; Nicolotti, Orazio; Catto, Marco; Pisani, Leonardo; Tardia, Piero; Introcaso, Antonellina; Valentina, Leo; Addabbo, Francesco; Montagnani, Monica; Nacci, Carmela
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds
2015-01-01 Pisani, L.; Farina, R.; Catto, M.; Nicolotti, O.; Soto-Otero, R.; Denora, N.; Altomare, C. D.; Carotti, A.
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases
2015-01-01 Farina, Roberta; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Gadaleta, Domenico; Denora, Nunzio; Soto Otero, R; Mendez Alvarez, E; Passos, Cs; Muncipinto, Giovanni; Altomare, Cosimo Damiano; Nurisso, A; Carrupt, Pa; Carotti, Angelo
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors
2015-01-01 Pisani, Leonardo; Farina, R; Nicolotti, Orazio; Gadaleta, D; Soto Otero, R; Catto, Marco; Di Braccio, M; Mendez Alvarez, E; Carotti, Angelo
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase
2015-01-01 Stefanachi, A; Hanke, N; Pisani, L; Leonetti, F; Nicolotti, O; Catto, M; Cellamare, S; Hartmann, Rw; Carotti, A
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors.
2015-01-01 Pau, A; Catto, Marco; Pinna, G; Frau, S; Murineddu, G; Asproni, B; Curzu, Mm; Pisani, Leonardo; Leonetti, Francesco; Loza, Mi; Brea, J; Pinna, Ga; Carotti, Angelo
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases | 1-gen-2011 | Pisani, Leonardo; Catto, Marco; Leonetti, Francesco; Nicolotti, Orazio; Stefanachi, Angela; Campagna, Francesco; Carotti, Angelo | |
| Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors | 1-gen-2011 | Stefanachi, Angela; Favia, A. D.; Nicolotti, Orazio; Leonetti, F; Pisani, Leonardo; Catto, Marco; Zimmer, C; Hartmann, R. W.; Carotti, Angelo | |
| Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease | 1-gen-2011 | Tasso, B; Catto, Marco; Nicolotti, Orazio; Novelli, F; Tonelli, M; Giangreco, I; Pisani, Leonardo; Sparatore, A; Boido, V; Carotti, Angelo; Sparatore, F. | |
| 6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors | 1-gen-2011 | Barletta, M.; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Soto Otero, R.; Carotti, Angelo | |
| Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase | 1-gen-2011 | Stefanachi, Angela; Favia, Ad; Nicolotti, Orazio; Leonetti, Francesco; Pisani, Leonardo; Catto, Marco; Zimmer, C; Hartmann, Rw; Cellamare, Saverio; Carotti, Angelo | |
| Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity | 1-gen-2011 | CONEJO GARCÍA, A; Pisani, Leonardo; DEL CARMEN NÚÑEZ, M; Catto, Marco; Nicolotti, Orazio; Leonetti, Francesco; Campos, J; Gallo, M; Espinosa, A; Carotti, Angelo | |
| Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams | 1-gen-2012 | Leonetti, Francesco; Muncipinto, G; Stefanachi, Angela; Nicolotti, Orazio; Cellamare, Saverio; Catto, Marco; Pisani, Leonardo; Pellegrino, G; Carotti, Angelo | |
| New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia | 1-gen-2012 | Stefanachi, Angela; Leonetti, Francesco; Nicolotti, Orazio; Catto, Marco; Pisani, Leonardo; Cellamare, Saverio; Altomare, Cosimo Damiano; Carotti, Angelo | |
| Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 | 1-gen-2012 | Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo | |
| 4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders | 1-gen-2013 | Pisani, L.; Catto, M.; Stefanachi, A.; Leonetti, F.; Campagna, F.; Nicolotti, O.; Soto-Otero, R.; Carotti, A. | |
| 4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS | 1-gen-2013 | Pisani, Leonardo; Catto, Marco; Stefanachi, Angela; Leonetti, F; Campagna, Francesco; Nicolotti, O; SOTO OTERO, R; Carotti, A. | |
| Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors | 1-gen-2013 | Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, G; Di Braccio, M; Soto Otero, R; Mendez Alvarez, E; Stefanachi, Angela; Gadaleta, G; Carotti, Angelo | |
| Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase | 1-gen-2013 | Catto, Marco; Pisani, Leonardo; Leonetti, Francesco; Nicolotti, Orazio; Pesce, Paolo; Stefanachi, Angela; Cellamare, Saverio; Carotti, Angelo | |
| Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors | 1-gen-2013 | Pisani, Leonardo; Barletta, Maria; Soto Otero, Ramon; Nicolotti, Orazio; Mendez Alvarez, Estefania; Catto, Marco; Introcaso, Antonellina; Stefanachi, Angela; Cellamare, Saverio; Altomare, Cosimo Damiano; Carotti, Angelo | |
| (EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK | 1-gen-2014 | Cellamare, Saverio; Carotti, Angelo; Stefanachi, Angela; Leonetti, Francesco; Nicolotti, Orazio; Catto, Marco; Pisani, Leonardo; Tardia, Piero; Introcaso, Antonellina; Valentina, Leo; Addabbo, Francesco; Montagnani, Monica; Nacci, Carmela | |
| Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds | 1-gen-2015 | Pisani, L.; Farina, R.; Catto, M.; Nicolotti, O.; Soto-Otero, R.; Denora, N.; Altomare, C. D.; Carotti, A. | |
| Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases | 1-gen-2015 | Farina, Roberta; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Gadaleta, Domenico; Denora, Nunzio; Soto Otero, R; Mendez Alvarez, E; Passos, Cs; Muncipinto, Giovanni; Altomare, Cosimo Damiano; Nurisso, A; Carrupt, Pa; Carotti, Angelo | |
| In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors | 1-gen-2015 | Pisani, Leonardo; Farina, R; Nicolotti, Orazio; Gadaleta, D; Soto Otero, R; Catto, Marco; Di Braccio, M; Mendez Alvarez, E; Carotti, Angelo | |
| Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase | 1-gen-2015 | Stefanachi, A; Hanke, N; Pisani, L; Leonetti, F; Nicolotti, O; Catto, M; Cellamare, S; Hartmann, Rw; Carotti, A | |
| Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. | 1-gen-2015 | Pau, A; Catto, Marco; Pinna, G; Frau, S; Murineddu, G; Asproni, B; Curzu, Mm; Pisani, Leonardo; Leonetti, Francesco; Loza, Mi; Brea, J; Pinna, Ga; Carotti, Angelo |
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