LA SPADA, GABRIELLA
LA SPADA, GABRIELLA
DIPARTIMENTO DI FARMACIA-SCIENZE DEL FARMACO
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors
2023-01-01 Rullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; Gottinger, Andrea; Catto, Marco; Delre, Pietro; Mastromarino, Margherita; Latronico, Tiziana; Marchese, Sara; Mangiatordi, Giuseppe Felice; Binda, Claudia; Linusson, Anna; Liuzzi, Grazia Maria; Pisani, Leonardo
From classical MTDLs to a semi-synthetic innovative green approach: nature-inspired design as a new intriguing opportunity for new anti-Alzheimer’s drugs
2024-01-01 Leuci, Rosalba; Carrieri, Antonio; Wackerlig, Judith; Chaves, Silvia; Catto, Marco; Laghezza, Antonio; Brunetti, Leonardo; LA SPADA, Gabriella; Loiodice, Fulvio; Tortorella, Paolo; Carocci, Alessia; Simic, Stefan; Amelia Santos, Maria; Gambacorta, Lucia; Gallo, Antonia; Perrone, Giancarlo; Piemontese, Luca
New rivastigmine-like compounds for the potential treatment of Alzheimer’s disease: a multi-target approach
2023-01-01 Leuci, Rosalba; Simic, Stefan; Brunetti, Leonardo; LA SPADA, Gabriella; Tortorella, Paolo; Loiodice, Fulvio; Laghezza, Antonio; Catto, Marco; Carrieri, Antonio; Wackerlig, Judith; Piemontese, Luca
Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease
2023-01-01 Hafez, Donia E.; Dubiel, Mariam; La Spada, Gabriella; Catto, Marco; Reiner-Link, David; Syu, Yu-Ting; Abdel-Halim, Mohammad; Hwang, Tsong-Long; Stark, Holger; Abadi, Ashraf H.
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates
2024-01-01 Leuci, Rosalba; Simic, Stefan; Carrieri, Antonio; Chaves, Sílvia; Spada, Gabriella La; Brunetti, Leonardo; Tortorella, Paolo; Loiodice, Fulvio; Laghezza, Antonio; Catto, Marco; Santos, M. Amélia; Tufarelli, Vincenzo; Wackerlig, Judith; Piemontese, Luca
Rivastigmine-based hybrids: a multi-target approach to anti-Alzheimer’s drug design
2023-01-01 Leuci, Rosalba; Simic, Stefan; Brunetti, Leonardo; LA SPADA, Gabriella; Tortorella, Paolo; Loiodice, Fulvio; Laghezza, Antonio; Catto, Marco; Carrieri, Antonio; Wackerlig, Judith; Piemontese, Luca
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization
2024-01-01 La Spada, Gabriella; Miniero, Daniela Valeria; Rullo, Mariagrazia; Cipolloni, Marco; Delre, Pietro; Colliva, Carolina; Colella, Marco; Leonetti, Francesco; Liuzzi, Grazia Maria; Mangiatordi, Giuseppe Felice; Giacchè, Nicola; Pisani, Leonardo
Synthesis, Molecular Electron Density Theory Study, Molecular Docking, and Pharmacological Evaluation of New Coumarin–Sulfonamide–Nitroindazolyl–Triazole Hybrids as Monoamine Oxidase Inhibitors
2024-01-01 Eddahmi, Mohammed; La Spada, Gabriella; Domingo, Luis R.; Vergoten, Gérard; Bailly, Christian; Catto, Marco; Bouissane, Latifa
Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles
2023-01-01 Eddahmi, Mohammed; La Spada, Gabriella; Hafid, Abderrafia; Khouili, Mostafa; Catto, Marco; Bouissane, Latifa
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors | 1-gen-2023 | Rullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; Gottinger, Andrea; Catto, Marco; Delre, Pietro; Mastromarino, Margherita; Latronico, Tiziana; Marchese, Sara; Mangiatordi, Giuseppe Felice; Binda, Claudia; Linusson, Anna; Liuzzi, Grazia Maria; Pisani, Leonardo | |
| From classical MTDLs to a semi-synthetic innovative green approach: nature-inspired design as a new intriguing opportunity for new anti-Alzheimer’s drugs | 1-gen-2024 | Leuci, Rosalba; Carrieri, Antonio; Wackerlig, Judith; Chaves, Silvia; Catto, Marco; Laghezza, Antonio; Brunetti, Leonardo; LA SPADA, Gabriella; Loiodice, Fulvio; Tortorella, Paolo; Carocci, Alessia; Simic, Stefan; Amelia Santos, Maria; Gambacorta, Lucia; Gallo, Antonia; Perrone, Giancarlo; Piemontese, Luca | |
| New rivastigmine-like compounds for the potential treatment of Alzheimer’s disease: a multi-target approach | 1-gen-2023 | Leuci, Rosalba; Simic, Stefan; Brunetti, Leonardo; LA SPADA, Gabriella; Tortorella, Paolo; Loiodice, Fulvio; Laghezza, Antonio; Catto, Marco; Carrieri, Antonio; Wackerlig, Judith; Piemontese, Luca | |
| Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease | 1-gen-2023 | Hafez, Donia E.; Dubiel, Mariam; La Spada, Gabriella; Catto, Marco; Reiner-Link, David; Syu, Yu-Ting; Abdel-Halim, Mohammad; Hwang, Tsong-Long; Stark, Holger; Abadi, Ashraf H. | |
| Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates | 1-gen-2024 | Leuci, Rosalba; Simic, Stefan; Carrieri, Antonio; Chaves, Sílvia; Spada, Gabriella La; Brunetti, Leonardo; Tortorella, Paolo; Loiodice, Fulvio; Laghezza, Antonio; Catto, Marco; Santos, M. Amélia; Tufarelli, Vincenzo; Wackerlig, Judith; Piemontese, Luca | |
| Rivastigmine-based hybrids: a multi-target approach to anti-Alzheimer’s drug design | 1-gen-2023 | Leuci, Rosalba; Simic, Stefan; Brunetti, Leonardo; LA SPADA, Gabriella; Tortorella, Paolo; Loiodice, Fulvio; Laghezza, Antonio; Catto, Marco; Carrieri, Antonio; Wackerlig, Judith; Piemontese, Luca | |
| Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization | 1-gen-2024 | La Spada, Gabriella; Miniero, Daniela Valeria; Rullo, Mariagrazia; Cipolloni, Marco; Delre, Pietro; Colliva, Carolina; Colella, Marco; Leonetti, Francesco; Liuzzi, Grazia Maria; Mangiatordi, Giuseppe Felice; Giacchè, Nicola; Pisani, Leonardo | |
| Synthesis, Molecular Electron Density Theory Study, Molecular Docking, and Pharmacological Evaluation of New Coumarin–Sulfonamide–Nitroindazolyl–Triazole Hybrids as Monoamine Oxidase Inhibitors | 1-gen-2024 | Eddahmi, Mohammed; La Spada, Gabriella; Domingo, Luis R.; Vergoten, Gérard; Bailly, Christian; Catto, Marco; Bouissane, Latifa | |
| Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles | 1-gen-2023 | Eddahmi, Mohammed; La Spada, Gabriella; Hafid, Abderrafia; Khouili, Mostafa; Catto, Marco; Bouissane, Latifa |