RULLO, MARIAGRAZIA
RULLO, MARIAGRAZIA
DIPARTIMENTO DI FARMACIA-SCIENZE DEL FARMACO
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1
2019-01-01 Rullo, Mariagrazia; Niso, Mauro; Pisani, Leonardo; Carrieri, Antonio; Colabufo, Nicola Antonio; Cellamare, Saverio; Altomare, Cosimo Damiano
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease.
2021-01-01 Purgatorio, R.; Gambacorta, N.; Catto, M.; de Candia, M.; Pisani, L.; Rullo, M.; Nicolotti, O.; Altomare, C. D.
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview)
2018-01-01 Rullo, Mariagrazia; Pisani, Leonardo
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules
2022-01-01 Pisani, Leonardo; Catto, Marco; Muncipinto, Giovanni; Nicolotti, Orazio; Carrieri, Antonio; Rullo, Mariagrazia; Stefanachi, Angela; Leonetti, Francesco; Altomare, Cosimo
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors
2023-01-01 Rullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; Gottinger, Andrea; Catto, Marco; Delre, Pietro; Mastromarino, Margherita; Latronico, Tiziana; Marchese, Sara; Mangiatordi, Giuseppe Felice; Binda, Claudia; Linusson, Anna; Liuzzi, Grazia Maria; Pisani, Leonardo
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones
2019-01-01 Rullo, Mariagrazia; Catto, Marco; Carrieri, Antonio; de Candia, Modesto; Altomare, Cosimo damiano; Pisani, Leonardo
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors
2022-01-01 Paolino, Marco; Rullo, Mariagrazia; Maramai, Samuele; de Candia, Modesto; Pisani, Leonardo; Catto, Marco; Mugnaini, Claudia; Brizzi, Antonella; Cappelli, Andrea; Olivucci, Massimo; Corelli, Federico; Altomare, Cosimo D
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection
2022-01-01 Maio, F. D.; Rullo, M.; de Candia, M.; Purgatorio, R.; Lopopolo, G.; Santarelli, G.; Palmieri, V.; Papi, M.; Elia, G.; De Candia, E.; Sanguinetti, M.; Altomare, C. D.
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease
2021-01-01 Purgatorio, Rosa; de Candia, Modesto; Catto, Marco; Rullo, Mariagrazia; Pisani, Leonardo; Denora, Nunzio; Carrieri, Antonio; Nevskaya, Alisa A.; Voskressensky, Leonid G.; Altomare, Cosimo D.
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease
2021-01-01 Purgatorio, Rosa; Gambacorta, Nicola; DE CANDIA, Modesto; Catto, Marco; Rullo, Mariagrazia; Pisani, Leonardo; Nicolotti, Orazio; Altomare, Cosimo Damiano
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology
2023-01-01 Pisani, Leonardo; de Candia, Modesto; Rullo, Mariagrazia; Altomare, Cosimo D.
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors
2019-01-01 Pisani, Leonardo; Iacobazzi, Rosa Maria; Catto, Marco; Rullo, Mariagrazia; Farina, Roberta; Denora, Nunzio; Cellamare, Saverio; Altomare, Cosimo Damiano
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease
2018-01-01 Piemontese, Luca; Vitucci, Gabriele; Catto, Marco; Laghezza, Antonio; Perna, Filippo; Rullo, Mariagrazia; Loiodice, Fulvio; Capriati, Vito; Solfrizzo, Michele
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
2024-01-01 Al-Saad, Omar M.; Gabr, Moustafa; Darwish, Sarah S.; Rullo, Mariagrazia; Pisani, Leonardo; Miniero, Daniela Valeria; Liuzzi, Grazia Maria; Kany, Andreas M.; Hirsch, Anna K. H.; Abadi, Ashraf H.; Engel, Matthias; Catto, Marco; Abdel-Halim, Mohammad
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies
2022-01-01 Rullo, M.; Cipolloni, M.; Catto, M.; Colliva, C.; Miniero, D. V.; Latronico, T.; De Candia, M.; Benicchi, T.; Linusson, A.; Giacche, N.; Altomare, C. D.; Pisani, L.
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets.
2019-01-01 Catto, M.; Bolognino, I.; Giangregorio, N.; de Candia, M.; Pisani, L.; Purgatorio, R.; Rullo, M.; Altomare, C. D.; Cellamare, S.
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization
2024-01-01 La Spada, Gabriella; Miniero, Daniela Valeria; Rullo, Mariagrazia; Cipolloni, Marco; Delre, Pietro; Colliva, Carolina; Colella, Marco; Leonetti, Francesco; Liuzzi, Grazia Maria; Mangiatordi, Giuseppe Felice; Giacchè, Nicola; Pisani, Leonardo
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase
2018-01-01 Pisani, Leonardo; Rullo, Mariagrazia; Catto, Marco; de Candia, Modesto; Carrieri, Antonio; Cellamare, Saverio; Altomare, Cosimo D
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 | 1-gen-2019 | Rullo, Mariagrazia; Niso, Mauro; Pisani, Leonardo; Carrieri, Antonio; Colabufo, Nicola Antonio; Cellamare, Saverio; Altomare, Cosimo Damiano | |
| 3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. | 1-gen-2021 | Purgatorio, R.; Gambacorta, N.; Catto, M.; de Candia, M.; Pisani, L.; Rullo, M.; Nicolotti, O.; Altomare, C. D. | |
| 4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) | 1-gen-2018 | Rullo, Mariagrazia; Pisani, Leonardo | |
| A twenty-year journey exploring coumarin-based derivatives as bioactive molecules | 1-gen-2022 | Pisani, Leonardo; Catto, Marco; Muncipinto, Giovanni; Nicolotti, Orazio; Carrieri, Antonio; Rullo, Mariagrazia; Stefanachi, Angela; Leonetti, Francesco; Altomare, Cosimo | |
| Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors | 1-gen-2023 | Rullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; Gottinger, Andrea; Catto, Marco; Delre, Pietro; Mastromarino, Margherita; Latronico, Tiziana; Marchese, Sara; Mangiatordi, Giuseppe Felice; Binda, Claudia; Linusson, Anna; Liuzzi, Grazia Maria; Pisani, Leonardo | |
| Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones | 1-gen-2019 | Rullo, Mariagrazia; Catto, Marco; Carrieri, Antonio; de Candia, Modesto; Altomare, Cosimo damiano; Pisani, Leonardo | |
| Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors | 1-gen-2022 | Paolino, Marco; Rullo, Mariagrazia; Maramai, Samuele; de Candia, Modesto; Pisani, Leonardo; Catto, Marco; Mugnaini, Claudia; Brizzi, Antonella; Cappelli, Andrea; Olivucci, Massimo; Corelli, Federico; Altomare, Cosimo D | |
| Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection | 1-gen-2022 | Maio, F. D.; Rullo, M.; de Candia, M.; Purgatorio, R.; Lopopolo, G.; Santarelli, G.; Palmieri, V.; Papi, M.; Elia, G.; De Candia, E.; Sanguinetti, M.; Altomare, C. D. | |
| Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease | 1-gen-2021 | Purgatorio, Rosa; de Candia, Modesto; Catto, Marco; Rullo, Mariagrazia; Pisani, Leonardo; Denora, Nunzio; Carrieri, Antonio; Nevskaya, Alisa A.; Voskressensky, Leonid G.; Altomare, Cosimo D. | |
| First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease | 1-gen-2021 | Purgatorio, Rosa; Gambacorta, Nicola; DE CANDIA, Modesto; Catto, Marco; Rullo, Mariagrazia; Pisani, Leonardo; Nicolotti, Orazio; Altomare, Cosimo Damiano | |
| Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology | 1-gen-2023 | Pisani, Leonardo; de Candia, Modesto; Rullo, Mariagrazia; Altomare, Cosimo D. | |
| Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors | 1-gen-2019 | Pisani, Leonardo; Iacobazzi, Rosa Maria; Catto, Marco; Rullo, Mariagrazia; Farina, Roberta; Denora, Nunzio; Cellamare, Saverio; Altomare, Cosimo Damiano | |
| Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease | 1-gen-2018 | Piemontese, Luca; Vitucci, Gabriele; Catto, Marco; Laghezza, Antonio; Perna, Filippo; Rullo, Mariagrazia; Loiodice, Fulvio; Capriati, Vito; Solfrizzo, Michele | |
| Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity | 1-gen-2024 | Al-Saad, Omar M.; Gabr, Moustafa; Darwish, Sarah S.; Rullo, Mariagrazia; Pisani, Leonardo; Miniero, Daniela Valeria; Liuzzi, Grazia Maria; Kany, Andreas M.; Hirsch, Anna K. H.; Abadi, Ashraf H.; Engel, Matthias; Catto, Marco; Abdel-Halim, Mohammad | |
| Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies | 1-gen-2022 | Rullo, M.; Cipolloni, M.; Catto, M.; Colliva, C.; Miniero, D. V.; Latronico, T.; De Candia, M.; Benicchi, T.; Linusson, A.; Giacche, N.; Altomare, C. D.; Pisani, L. | |
| Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. | 1-gen-2019 | Catto, M.; Bolognino, I.; Giangregorio, N.; de Candia, M.; Pisani, L.; Purgatorio, R.; Rullo, M.; Altomare, C. D.; Cellamare, S. | |
| Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization | 1-gen-2024 | La Spada, Gabriella; Miniero, Daniela Valeria; Rullo, Mariagrazia; Cipolloni, Marco; Delre, Pietro; Colliva, Carolina; Colella, Marco; Leonetti, Francesco; Liuzzi, Grazia Maria; Mangiatordi, Giuseppe Felice; Giacchè, Nicola; Pisani, Leonardo | |
| Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase | 1-gen-2018 | Pisani, Leonardo; Rullo, Mariagrazia; Catto, Marco; de Candia, Modesto; Carrieri, Antonio; Cellamare, Saverio; Altomare, Cosimo D |