Post-traumatic chronic bone and joint infection caused by Butyricimonas spp, and treated with high doses of ertapenem administered subcutaneously in a 30-year-old obese man

An obese but otherwise healthy 30-year-old man presented with septic pseudarthrosis following a post-traumatic open radial fracture. Three months earlier, the patient had been involved in a truck accident and suffered a distal open radial fracture associated with compartment syndrome ( figure 1A). Primary management consisted of wound debridement, fasciotomy, stabilisation with external fixation and antibiotic prophylaxis with amoxicillin-clavulanate. The wound healed after 1 month ( figure 1B). Due to pseudarthrosis ( figure 1C, D), the patient returned to the operating room for internal fixation. He did not have fever, and there was no local sign of inflammation and no fistula; C reactive protein was <5 mg/L. Internal fixation was not performed, as a bone abscess in the facture site was discovered. Surgical samples revealed Bacteroides vulgatus, Clostridium tertium and Butyricimonas spp in cultures. MRI revealed several abscesses in the radius (figure 1E). As the patient refused central vascular access, he received prolonged high doses of ertapenem subcutaneously (1 g two times a day) for 3 months, with metro- nidazole during the first month, followed by clinda- mycin. The ertapenem (diluted in 50cc of physiological serum) was infused subcutaneously by butterfly disposable needle in the lower quadrants of the abdomen and alternately on the anterior side of a thigh ( figure 1F, G) during a 30–60 min gravity infusion. Arthrodesis was then performed and the outcome was favourable (figure 1H).