Angiogenesis is an important pathway of neoplastic growth and progression. Our several published studies suggest that angiogenesis represents an interspecies pathway of tumour growth due to its roles in several spontaneous canine tumour model. Stromal microenvironment, macrophages and mast cells play a main roles in tumour angiogenesis. Furthermore several recent studies strongly suggest that mast cells density and mast cell activation are correlated with microvascular density. In this context mast cells may stimulates angiogenesis by secretion of their angiogenetic factors such as Vascular Endothelial Growth Factor (VEGF), Tryptase and Chynase. VEGF represents the classical pro-angiogenic factor while Tryptase and Chynase are proteases that presents new pro-angiogenic factor. We aim to study the role of mast cells in neoplastic growth and progression in canine mast cell tumour model. Canine mast cell tumour model represents a unique model with well, intermediate and poorly differenziated tumour and differently angiogenetic activity. We aim to study with immunohistochemistry and ELISA methods primary mast cell tumour and mast cell tumour lines for the expression of angiogenic factors and mast cell activation. In this context will be possible to hypothesize the inhibition of pro-angiogenic factors and mast cell degranulation as a new anti-angiogentic and anti tumour therapy.
Mast cells and angiogenesis: the canine mast cell tumour as a unique tumour model to study the correlation between activated/degranulated mast cells and angiogenesis
ZIZZO, Nicola;PASSANTINO, Letizia;
2011-01-01
Abstract
Angiogenesis is an important pathway of neoplastic growth and progression. Our several published studies suggest that angiogenesis represents an interspecies pathway of tumour growth due to its roles in several spontaneous canine tumour model. Stromal microenvironment, macrophages and mast cells play a main roles in tumour angiogenesis. Furthermore several recent studies strongly suggest that mast cells density and mast cell activation are correlated with microvascular density. In this context mast cells may stimulates angiogenesis by secretion of their angiogenetic factors such as Vascular Endothelial Growth Factor (VEGF), Tryptase and Chynase. VEGF represents the classical pro-angiogenic factor while Tryptase and Chynase are proteases that presents new pro-angiogenic factor. We aim to study the role of mast cells in neoplastic growth and progression in canine mast cell tumour model. Canine mast cell tumour model represents a unique model with well, intermediate and poorly differenziated tumour and differently angiogenetic activity. We aim to study with immunohistochemistry and ELISA methods primary mast cell tumour and mast cell tumour lines for the expression of angiogenic factors and mast cell activation. In this context will be possible to hypothesize the inhibition of pro-angiogenic factors and mast cell degranulation as a new anti-angiogentic and anti tumour therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
