Introduction: To evaluate the tolerability of etoricoxb, a new COX-2 inhibitor, in Non Steroidal Anti-inflammatory Drugs (NSAIDs) sensitive patients with urticaria-type adverse reactions. Materials and methods: 37 patients with NSAIDs adverse reactions were submitted to a single blind, placebo controllerd oral challenge with increasing doses of Etoricoxib. Results: 34 patients tolerated Etoricoxib without adverse reactions, but 3 (7%) experienced a generalized urticarial rash. Conclusions: Etoricoxib, as well as other COX-2 inhibitors, represents a well tollerated drug in most of the NSAIDs sensitive patients, despite that, according to our experience, a previous challenge test in a safe enviroment should be necessary before prescibing it to the patient.

Tolerability of Etoricoxib in patients affected by Non Steroidal Anti-Inflammatory drugs induced urticaria: A single blind placebo study on 37 subjects

Ventura M. T.;
2005-01-01

Abstract

Introduction: To evaluate the tolerability of etoricoxb, a new COX-2 inhibitor, in Non Steroidal Anti-inflammatory Drugs (NSAIDs) sensitive patients with urticaria-type adverse reactions. Materials and methods: 37 patients with NSAIDs adverse reactions were submitted to a single blind, placebo controllerd oral challenge with increasing doses of Etoricoxib. Results: 34 patients tolerated Etoricoxib without adverse reactions, but 3 (7%) experienced a generalized urticarial rash. Conclusions: Etoricoxib, as well as other COX-2 inhibitors, represents a well tollerated drug in most of the NSAIDs sensitive patients, despite that, according to our experience, a previous challenge test in a safe enviroment should be necessary before prescibing it to the patient.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/228252
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