Phosphonoformate – the simplest member of the group of phosphono-carboxylic-acids containing a phosphonic as well as a directly bonded carboxylic moiety - can be regarded as a structural mimic of the pyrophosphate anion, a very important building block in biochemistry involved in processes of energy transfer as well as in growth of DNA or RNA strands. This derivative selectively inhibits the pyrophosphate binding side on viral polymerases, which qualifies the title compound as an antiviral medication used in the treatment of herpes viruses including drug-resistant cytomegaloviruses and as part of salvage therapy for highly treatment-experienced patients infected with HIV. Surprisingly only the crystal structure of the widely used trisodium salt is reported in the literature, whereas the coordination behavior towards other (earth) alkaline as well as transition metals is still unexplored. First insights into this field are reported in this work.

Versatile coordination chemistry of the phosphonoformate anion

Sara Barile;Vito Capriati;
2019-01-01

Abstract

Phosphonoformate – the simplest member of the group of phosphono-carboxylic-acids containing a phosphonic as well as a directly bonded carboxylic moiety - can be regarded as a structural mimic of the pyrophosphate anion, a very important building block in biochemistry involved in processes of energy transfer as well as in growth of DNA or RNA strands. This derivative selectively inhibits the pyrophosphate binding side on viral polymerases, which qualifies the title compound as an antiviral medication used in the treatment of herpes viruses including drug-resistant cytomegaloviruses and as part of salvage therapy for highly treatment-experienced patients infected with HIV. Surprisingly only the crystal structure of the widely used trisodium salt is reported in the literature, whereas the coordination behavior towards other (earth) alkaline as well as transition metals is still unexplored. First insights into this field are reported in this work.
File in questo prodotto:
File Dimensione Formato  
2019_Phosphorous_Silicon.pdf

non disponibili

Tipologia: Documento in Versione Editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 1.2 MB
Formato Adobe PDF
1.2 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/227501
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 0
social impact