AIM: The aim of this study is to investigate the T helper (Th)2-dependent release of interleukin(IL)-4 and IL-13 in patients with unstable angina treated with coronary angioplasty (PCI). METHODS: This study involved 48 consecutive patients with unstable angina who underwent PCI. Blood samples were taken before and 48 h after PCI to evaluate serum IL-4 and IL-13 levels. Coronary atherosclerosis was assessed in terms of the severity of the treated lesions and the presence of multivessel disease, and compared with IL release. RESULTS: Before and after PCI, serum IL-4 levels were, respectively, 53.1±110.7 and 35.1±16.9 pg/ml (P not significant), and serum IL-13 levels 6.7±3.7 and 6.0±2.9 pg/ml (P<0.05). A correlation was present between the severity of the treated coronary lesions and serum IL-13 levels (r 0.36; P<0.05). The patients with multivessel coronary artery disease had a higher periprocedure ratio of IL-4 than those with single-vessel coronary artery disease (1.46±0.76 vs. 0.89±0.34, P<0.001). CONCLUSION: A significant decrease was observed in Th2-dependent IL concentrations after PCI; increased Th2-dependent IL levels before PCI seem to correlate with the severity of coronary atherosclerosis. © 2008 Lippincott Williams & Wilkins, Inc.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
|Titolo:||Th2-dependent cytokine release in patients treated with coronary angioplasty|
|Data di pubblicazione:||2008|
|Citazione:||Th2-dependent cytokine release in patients treated with coronary angioplasty / Brunetti, Natale Daniele; Pepe, Martino; Munno, Irene; Tiecco, Fabio; Quagliara, Donato; De Gennaro, Luisa; Gaglione, Antonio; Di Biase, Matteo; Favale, Stefano. - In: CORONARY ARTERY DISEASE. - ISSN 0954-6928. - 19:3(2008), pp. 133-137.|
|Appare nelle tipologie:||1.1 Articolo in rivista|