A new simple and stereoselective synthesis of 5-isoxazolidinones based on the reaction of lithiated 2-isopropyl-2-oxazolines with nitrones is described. A chiral version of such a methodology allows the preparation of highly enantioenriched 5-isoxazolidinones which are useful precursors for the synthesis of β-amino acids.

New Synthesis of Optically Active 5-Isoxazolidinones and beta-Amino Acids

LUISI, Renzo;CAPRIATI, Vito;
2003-01-01

Abstract

A new simple and stereoselective synthesis of 5-isoxazolidinones based on the reaction of lithiated 2-isopropyl-2-oxazolines with nitrones is described. A chiral version of such a methodology allows the preparation of highly enantioenriched 5-isoxazolidinones which are useful precursors for the synthesis of β-amino acids.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/136229
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