A novel brain-specific antigen, called Sy-1, has been identified in whole rat brain hypotonic extracts by means of an antiserum produced in rabbits against the synaptosomal cytosol. Sy-1 is an acidic protein (pI 4.7) present exclusively in a soluble form and it does not carry any sugar moiety. Sy-1 is found only in rat brain and, in a partially identical form, in mouse brain. In rat brain the antigen is more concentrated in the brainstem than in the forebrain and cerebellum. On the basis of immunological, physico-chemical and biological criteria Sy-1 differs from other, already described, brain-specific proteins.
A novel soluble brain-specific protein (Sy-1):identification and partial characterization
GENNARINI, Gianfranco;CORSI, Patrizia;
1983-01-01
Abstract
A novel brain-specific antigen, called Sy-1, has been identified in whole rat brain hypotonic extracts by means of an antiserum produced in rabbits against the synaptosomal cytosol. Sy-1 is an acidic protein (pI 4.7) present exclusively in a soluble form and it does not carry any sugar moiety. Sy-1 is found only in rat brain and, in a partially identical form, in mouse brain. In rat brain the antigen is more concentrated in the brainstem than in the forebrain and cerebellum. On the basis of immunological, physico-chemical and biological criteria Sy-1 differs from other, already described, brain-specific proteins.File in questo prodotto:
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