The combined use of Pd(OAc)2, Cu(OAc)2, and dioxygen in molten tetrabutylammonium acetate (TBAA) promotes an unusual cyclopropanation reaction between aryl methyl ketones and styrenes. The process is a dehydrogenative cyclizing coupling that involves a twofold CH activation at the a-position of the ketone. The substrate scope highlights the flexibility of the catalyst; a reaction mechanism is also proposed.
Palladium-Catalyzed Cross-Coupling of Styrenes with Aryl Methyl Ketones in Ionic Liquids: Direct Access to Cyclopropanes
Cotugno P;Monopoli A;CIMINALE, Francesco;MILELLA, ANTONELLA;NACCI, Angelo
2014-01-01
Abstract
The combined use of Pd(OAc)2, Cu(OAc)2, and dioxygen in molten tetrabutylammonium acetate (TBAA) promotes an unusual cyclopropanation reaction between aryl methyl ketones and styrenes. The process is a dehydrogenative cyclizing coupling that involves a twofold CH activation at the a-position of the ketone. The substrate scope highlights the flexibility of the catalyst; a reaction mechanism is also proposed.File in questo prodotto:
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