A series of alkyloxyquinoline derivatives has been developed to evaluate the relationship between P-gp potency and lipophilicity. The results show a satisfactory lipophilicity-activity correlation although a series of derivatives showing higher P-gp potency is needed in order to confirm this hypothesis.
A series of alkyloxyquinoline derivatives has been developed to evaluate the relationship between P-gp potency and lipophilicity. The results show a satisfactory lipophilicity-activity correlation although a series of derivatives showing higher P-gp potency is needed in order to confirm this hypothesis. © 2013 Elsevier Ltd. All rights reserved.
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments
Contino, Marialessandra;Zinzi, Laura;Cantore, Mariangela;Perrone, Maria Grazia;Leopoldo, Marcello;Berardi, Francesco;Perrone, Roberto;Colabufo, Nicola Antonio
2013-01-01
Abstract
A series of alkyloxyquinoline derivatives has been developed to evaluate the relationship between P-gp potency and lipophilicity. The results show a satisfactory lipophilicity-activity correlation although a series of derivatives showing higher P-gp potency is needed in order to confirm this hypothesis. © 2013 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.