Calcific aortic valve disease (CAVD) represents a slowly progressive pathologic process associated with major morbidity and mortality. The process is characterized by multiple steps: inflammation, fibrosis, and calcification. Numerous studies focalised on its physiopathology highlighting different “actors” for the multiple “acts”. This review focuses on the role of the tumor necrosis factor superfamily (TNFSF) members in the pathogenesis of CAVD. In particular we discuss on clinical and experimental studies providing evidence of the involvement of tumor necrosis factor alpha (TNF-α), receptor activator of nuclear factor kappa-B (NF-kB) ligand (RANKL), its membrane receptor RANK and its decoy receptor osteoprotegerin (OPG), and TNF-related apoptosis-inducing ligand (TRAIL) in valvular calcification.
The role of tnf-alpha and tnf superfamily members in the pathogenesis of calcific aortic valvular disease
PAPARELLA, Domenico;COLUCCI, Silvia Concetta;GRANO, Maria;BRUNETTI, GIACOMINA
2013-01-01
Abstract
Calcific aortic valve disease (CAVD) represents a slowly progressive pathologic process associated with major morbidity and mortality. The process is characterized by multiple steps: inflammation, fibrosis, and calcification. Numerous studies focalised on its physiopathology highlighting different “actors” for the multiple “acts”. This review focuses on the role of the tumor necrosis factor superfamily (TNFSF) members in the pathogenesis of CAVD. In particular we discuss on clinical and experimental studies providing evidence of the involvement of tumor necrosis factor alpha (TNF-α), receptor activator of nuclear factor kappa-B (NF-kB) ligand (RANKL), its membrane receptor RANK and its decoy receptor osteoprotegerin (OPG), and TNF-related apoptosis-inducing ligand (TRAIL) in valvular calcification.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
